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Antoris MR 35mg Tablet 1 Strip
Antoris MR, (Trimetazidine Dihydrochloride Modified Release Tablets), Therapeutic Class: Other Anti-anginal & Anti-ischemic Agents
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✅ Description:
Antoris MR is indicated as an adjunctive treatment in adults with stable angina pectoris, particularly for patients who are not adequately managed with, or are intolerant to, standard first-line anti-anginal therapies.
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✔️ Antoris MR is generally well tolerated. Commonly reported side effects include:
- Dizziness, headache
- Gastrointestinal disturbances: abdominal pain, diarrhea, nausea, vomiting, dyspepsia
- Skin reactions: rash, pruritus, urticaria
- Fatigue or asthenia
✔️ Pharmacology / Mechanism of Action:
Trimetazidine is the first 3-ketoacyl CoA thiolase (KAT) inhibitor, a metabolic agent that enhances cardiac efficiency under ischemic conditions. It shifts energy production from fatty acid oxidation to glucose oxidation by inhibiting the KAT enzyme. Since glucose metabolism yields more energy per unit of oxygen consumed, this shift improves myocardial efficiency and oxygen utilization. It also helps prevent intracellular acidosis and preserves cellular homeostasis, effectively reducing angina symptoms without affecting hemodynamic parameters.
✔️ Dosage & Administration:
Recommended Adult Dose:
Modified release: 35 mg twice daily
Immediate release: 20 mg three times daily
Administration: Take with meals.
Re-evaluation: Assess response to treatment after 3 months. If no clinical benefit is observed, discontinuation is advised.
✔️ Drug Interactions:
No significant drug interactions have been reported. Antoris MR can be safely co-administered with:
- Beta-blockers
- Calcium channel blockers
- Nitrates
- Heparin
- Lipid-lowering agents
- Cardiac glycosides
✔️ Contraindications:
- Known hypersensitivity to Trimetazidine or any formulation components
- Parkinson’s disease and related movement disorders (e.g., tremors, restless legs syndrome)
- Severe renal impairment (eGFR <30 mL/min/1.73m²)
✔️ Use in Pregnancy & Lactation:
Pregnancy: Data on human use is limited; animal studies show no direct reproductive toxicity. Use only if needed.
Breastfeeding: Unknown whether excreted in breast milk. Due to the potential risk to infants, use is not recommended during lactation.
✔️ Precautions & Warnings:
Antoris MR is not intended to treat acute angina episodes, unstable angina, or acute myocardial infarction.
It should be used as part of a long-term strategy, not as first-line monotherapy.
✔️ Storage Instructions:
Store in a cool, dry place, away from direct heat and light. Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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